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KMID : 0861420120160020049
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Korean Journal of Nuclear Medicine Technology
2012 Volume.16 No. 2 p.49 ~ p.56
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The Correlation Analysis of Ejection Fraction: Comparison of 201Tl gated Myocardial Perfusion SPECT and Echocardiography
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Yoon Soon-Sang
Ryu Jae-Kwang
Cha Min-Kyoung
Lee Jong-Hun
Kim Sung-Hwan
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Abstract
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Purpose:Gated myocardial perfusion SPECT provides not only myocardial perfusion status, but various
functional parameters of left ventricle (LV). The purpose of this study was to analyze ejection fraction (EF) for
correlation and difference between 201Tl gated myocardial perfusion SPECT and echocardiography depending
on extent of perfusion defect, gender and LV volumes.
Materials and Methods:From April 2011 to May 2012, we analyzed 291 patients (male:female =165:126; mean: 64.6±10.8 years) who were examined both 201Tl gated myocardial perfusion SPECT and echocardiography at less than 7 days apart in our hospital. 101 patients showed perfusion defect and the rest of the people without any defect. We applied automatic analysis (Quantitative gated SPECT, QGS), and calculated EF, End-diastolic volume (EDV) and End-systolic volume (ESV) from Stress (G-Stress) and Rest (G-Rest) studies. And we analyzed the correlation and difference for EF
between 201Tl gated SPECT and echocardiography.
Results:The correlation of LVEF among G-Stress, G-Rest
and echocardiography was quite a good (G-Stress vs. G-Rest: r=0.909, G-Stress vs. echocardiography: r=0.833,
G-Rest vs. echocardiography: r=0.825). And there were significant differences in EDV, ESV and EF in total
patients (p<0.01). The normal group showed significant difference in EF (p<0.01) and the group with perfusion
defect also demonstrated significant difference (a group with reversible defect: p<0.01, fixed defect: p<0.01)
depending on extent of perfusion defect. We analyzed difference in normal group by gender. In normal group,
there was no significant difference (p>0.05) in EF from men. However, there was a significant difference
(p<0.01) from women. When we classified two groups by average size of EDV in Korean women, there was no
significant difference in a group of above average size of EDV (p>0.05).
Conclusion:When compared among Stress and Rest of 201Tl gated SPECT and echocardiography, we confirmed that there was a good correlation for LVEF. But there were significant differences among three studies. And extent of perfusion defect, gender and LV volumes are independent determinants of the accuracy of LVEF. So, it is hard to compare and interchange quantitative indices among modalities. We should take additional researches to prove results of our study
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KEYWORD
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Myocardial perfusion SPECT, Echocardiography, Quantitative gated SPECT, Ejection fraction
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